country road of netherlands

river surrounded by forests

It has been shown to have a surprising effect on the results of a trial and practice in the middle of the city. However, if you are a patient with obesity, help your child with weight loss?

When we arrived at Susan-Australia, the hotel banquet scientist was fully seated. After 10 minutes of exhaustion, there were only a few vacancies in the immediate vicinity. In November 2022, at the annual obesity conference held by the Sanctuary of California in California, many people were expected to receive the expected results of the physical examination.

The lecturer--the researcher of the company who belonged to the company--there was a disappointment. Others have described a kind of anti-obesity anti-obesity material for youth, and it is well known that this group has this kind of therapeutic resistance. The results of the study were astonishing: the first injection, continued for about 16 months, followed by a slight change in lifestyle, over a third of the participants' body weight decreased by 20%1. Previous research 2, 3 presentations, this kind of thing--I'm sorry, I'm a middle-aged person and I'm seriously impressed.

Yanovski, Co-Director of Obesity Research Office, National Institute of Diabetes, Gastrointestinal and Endopathic Diseases, National Institute of Diabetes and Gastroenterology, National Institute of Diabetes and Digestive Diseases, State Department of Mauritania, said: A long-awaited rendition of a hand-held voice in the room, "You can see the image of a hundred years old."

Over the past few years, this kind of capacity is directly related to the medical field of obesity. After ten years of effort, researchers have finally seen a successful result: a new era of anti-obesity can significantly reduce weight, but there have been serious side effects since the effort.

This trivial thing is the arrival of an era of obesity index. According to the World Health Organization (WHO) statistics, since 1975, obesity has doubled worldwide; in 2016, about 40% of adults suffer from overweight, and 13% of people suffer from obesity. External weight and concomitant health conditions such as type 2 diabetes, heart disease and certain cancers. With the adoption of healthy eating and physical education activities in the world organization, obesity will be reduced, but if there is a change in the lifestyle, there is a medical treatment available. This new model is called an increase in weight, which reduces hypoglycemia and suppresses appetite. A few things have been approved for the treatment of type 2 diabetes, and it has been approved for the first time.

Through the adjustment of biology, the ability to use weight gain is a kind of disease. In the past, scientists and the public have seen only a few obesity patients with a lack of willpower. However, the majority of people's bodies have a natural size, which is very difficult to change. "A chemist at Indo Ansu University, Fuuo Ming Branch Campus: "Physical health care self-weight."

However, a little researcher's concern, this kind of thing has been released, a kind of lost love for society. Physical size and discomfort are healthy factors. "Sarah Nutter, a psychologist at Kaman University, said:" I really want to see the angle of weight gain, and this kind of possibility can be harmful.

Compared to the research question, everyone has a response to the treatment in the comprehensive meeting, and people must take this trivial thing -- this is a huge obstacle, because there is a price tag for the injection: monthly injection costs over 1000. Beauty.

As you can see, obesity researchers have made some progress. According to Matthias Tschöp, the chief executive officer of the De Guo Munyi Group, a medical student and scientist, this is the first change in weight that scientists can pass through. "This is a 'transformative breakthrough'".

The successful seeds
of this era have been disseminated ten years ago. In 1994, a molecular philosopher at Luxembourg University in New York City, De Man, released a problematic root cause, which is a kind of adipose tissue production stimulus, causing hunger 4. Deficiency in small intestinal supplements, it is possible to reduce hunger and weight.

"Against the basics:" This has completely changed our basic biological thinking for obesity and appetite.

Subsequently, explosive research on the basis of obesity has progressed, and at the same time, research on physical therapy has progressed. However, this early weight reduction and serious side effects, especially the effect on the mind.

Prior to its discovery, a researcher had been working on a hyperglycemia level hyperglycemia, and a type of GLP-1 (hyperglycemia hyperglycemia 1) hyperglycemia had been discovered. According to Jens Juul Holst, a medical physiologist at Hargen University, Reciprocal effects of type 2 diabetes mellitus with similar equipment -- GLP-1 increased secretion and hypoglycemia 5 -- used to form a type of therapeutic obesity with suction power method, and features of GLP-1 that have been published and described by others.

In the 2000s, the US Food and Drug Administration (FDA) started to ratify GLP-1-based drugs to treat type 2 diabetes mellitus (see "Weight Star"). However, scientists should be careful, because GLP-1 has a large appetite-controlling receptor and a digestive receptor-reducing effect on the digestive system, and the person who participates in the floor trial also reduces their weight. Accompanying time transition, the company started the trial, this is a diabetic fertility reduction effect. By the mid-2010s, one of them had a weight average drop of about 8%, and many people took tranquilizers to the 5th percentile.

However, at the beginning of 2021, there will be two shocking events in the same type of research conducted by scientists. DiMarchi says, this kind of molecule is an improved version, works with a homologous path, but has a complete internal retention and active time change. In addition, it is possible to enter a large area with improved appetite.

Patients receiving weekly injections of semaglutide after 16 months of treatment had an average weight reduction of 14.9%; In 2021, four years after being approved for diabetes treatment, the US Food and Drug Administration approved semaglutide for adult obesity patients.

Biologist Timo Müller, Director of the Diabetes and Obesity Research Institute, said, "It's impossible to pass the weight of a safe place. Reduce your weight by more than 10%." However, this new treatment method also improves cardiovascular health--it is a contradiction in the past.

Currently, there is only one kind of more effective food: Dallas. Tirzepatide is not the only receptor for GLP-1 receptors; it is a type of stimulant that participates in the secretion of liposomes, which is glucose-dependent liposomes (GIP). 2022 ratification for treatment of type 2 diabetes, this type of treatment method--developed by India's No. 2020 Anxiety Relief Company--average weight loss under the maximum dose of the drug is 21%, and the comfort drug is 3% 7.

In the immediate future, there are two types of models, and only one type of model is very effective. According to Müller, it is possible to use a more effective GLP-1 receptor stimulant, and GIP can help with GLP-1 side effects. It is also possible to reduce the weight by self-propulsion, which is possible with GIP.

The existence of exhaustion is uncertain, but the weight reduction horizontal approach after treatment is usually only available through the reduction of the surgical talent. After 6 months of this type of surgery, the weight has decreased by 30% or more, and the weight loss has been reduced for the next two years.

"Ten years ago, if you told me that we have one kind of East and West possible, we would be very close [reduction procedure], I would say this is impossible." Written by Ruth Gimeno. Before the results of the second phase III trial of the company's plan were completed in April 2023, the application was ratified.

The results of the machine 's exhaustion were hopeful, but the researchers were perplexed. The neat and clean GLP-1 is very stimulating and fertile, but the effect of GIP is a surprise. In fact, scientists have learned to recognize GIP in practice: obesity resistance against GIP receptor dysfunction8. Because of this, because the researcher is responsible for this matter. However, it is a contradiction in terms of how it works.

"We are the first person to submit this crazy idea," said Müller. "And we have received a considerable amount of criticism."

Mu Le and other comrades--comprehensive DiMarchi and Tschöp--Chido GIP foundation base blood glucose horizontal stimulus hormone secretion, image GLP-1 one, Mu Le. There are two other types of radical molecules that have been developed. Initial research has demonstrated that active GIP and GLP-1 receptors have been associated with weight reduction, and the company has created other self-contained molecules that have reached the same effect, starting from the method effectiveness.
However, non-owners have been changed against GIP. It's just one super-strong GLP-1 model.

It is possible to model GIP, "However, for patients with diabetes and obesity, this is actually unimportant, because the GIP part does not have a genuine effect," Holst said. Lilai company is currently in progress, so GIP is a single-target material early trial, which is a controversy that is about to be resolved.

Located in California, Qianmu City Biological Pharmaceutical Company Amgen (Amgen) is currently researching a kind of active GLP-1 receptor and blocking GIP receptor. Indicated early floor trial number, this type of treatment after 12 weeks weight reduction 15% left and right.

Other methods include "triple stimulant", model GLP-1, GIP and the third type of hyperglycemia--hyperglycemic action, the latter also stimulates hyperglycemia secretion 9. There are others who participate in the gastrointestinal tract, such as YY, and also search for it. A small study in human studies of Bimagrumab, the antibody bimagrumab, simultaneously increased skin mass with reduced fat content.

Open problem
research is a big problem that people are currently facing, and people need to take this little thing to keep their weight. A group of participants who stopped taking semaglutide and stopped taking the Investigative Lifestyle Trial, after a year and a half lost weight by about 10%.

Another unknown number is someone's reaction to this trivial thing--no one. At present, it is too early to judge, but this small thing does not have the same effect on type 2 diabetic patients as it does on non-diabetic patients. Tschöp, fatty liver and peripheral organ fat (commonly known as internal fat) can also affect people with different physical reactions.

Some researchers are still concerned, and in a lean society, this kind of thing provides a kind of weight-solving method, and it is possible to inadvertently intensify it, and it is a controversial relationship between super heavy health. A recent research found that 30% of people with obesity are healthy 11. Another study stated that other health problems had the ability to change the weight over time.

"Based on a person's weight, other health conditions become pathological, which can be very harmful.

Because of the special care, people can avoid weight humiliation, but this minor side effect (such as heart and vomiting) is a serious treatment, but it does not satisfy genuine health needs.

Others care about this trivial thing and provide a quick fix idea. According to Leslie Heinberg, a floor psychologist at Katsurifu's office, this is a common misunderstanding of the technique, and other research studies have been conducted to reduce health and physical appearance. "Tell me: "A little bit of a human conversation, 'Well, this is a simple way to lose weight,' which is just what people are looking for right now."

Whatever the case, we have a large amount of demand. All of these things are available in the market, but if you don't own it, you can get it.

First of all, the price is high for the fat semaglutide, the product is Wegovy, the price is about 1300 Yuan per month, and the US insurance company refuses to pay this fee. In general, the method of viewing "fake hearts".

"Oath Action Alliance (OAC) Chairman Patty Nece said: "This is one of the things that people talk about. However, as a supplement, "For the patient to come, if there is no other responsibility or no law, it will be a factor that will change the game forever."

Image OAC This organization's current promotional control company provides a liability plan. For example, Lilai Co. is Mounjaro--Treatment Type 2 Diabetes Treatment Plan has been established as a "transit plan", which is based on the plan. A similar plan was established by Wegovy.

Due to the uncontrollable costs, some scientific efforts have been made to solve the problem, so that the health care system can be reduced, and a large amount of money has been made by the Ministry of Health.

Extensive research efforts by human resources to solve the causes of obesity recovery--comprehensive care, environmental harmonization--but many people support biology revealing important working points. Healthy eating and exercise are part of the cure at the beginning, but many people agree that this is a kind of hopeful fulfillment. Some researchers have observed that this is because of the biomechanical development that occurs through this process, and that the general staff understands that one person's lifestyle changes are restrained by other people's lifestyle changes.